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During viral pathogenesis, many viruses exploit host cell machinery to replicate their genome. Which of the following enzymes is MOST essential for retroviruses like HIV to integrate their genetic material into the host DNA?
Retroviruses use reverse transcriptase to convert RNA into DNA, but integrase is the enzyme that inserts this viral DNA into the host genome, enabling persistent infection and pathogenesis.
A new antiviral drug targets viral entry by blocking fusion of the viral envelope with the host cell membrane. Which stage of the viral life cycle does this intervention primarily disrupt?